CLSI H59-P: D-dimer is a product of fibrinolysis that is assayed in the blood. It is elevated following intravascular thrombosis, disseminatedintravascular coagulation (DIC), and other conditions that can cause fibrin generation. Assay of D-dimer is a useful tool whenevaluating patients with possible venous thromboembolism (VTE), the absence of D-dimer being helpful in excluding VTE.Clinical and Laboratory Standards Institute document H59-P–Quantitative D-dimer for the Exclusion of VenousThromboembolic Disease; Proposed Guideline provides guidance regarding the use of D-dimer in exclusion of VTE including adescription of the value of clinical determination of the pretest probability of VTE; the proper collection and handling of thespecimen; assays used for D-dimer analysis; determination of the threshold for exclusion of VTE; interpretation of test results;and aspects of regulatory and accreditation requirements. The guideline is provided for use by laboratorians; manufacturers of Ddimerassays; clinicians who use the D-dimer for VTE exclusion; and for accrediting and regulatory agencies.
- Published:
- 04/01/2010
- ISBN(s):
- 1562387235
- Number of Pages:
- 44
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